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Test ID A1AFS Alpha-1-Antitrypsin Clearance, Feces and Serum

Ordering Guidance

The recommended procedure for protein-losing enteropathy is A1AFS / Alpha-1-Antitrypsin Clearance, Feces and Serum.

Shipping Instructions

Feces and serum should be shipped together. Specimens shipped separately may delay testing.

Specimen Required

Both feces and serum are required.


Blood must be drawn during the stool collection period.


Specimen Type: Serum

Collection Container/Tube: Red top or serum gel

Submission Container/Tube: Plastic vial

Specimen Volume: 1 mL

Collection Instructions:

1. Centrifuge within 2 hours.

2. Aliquot and ship in plastic vial.


Specimen Type: Feces

Supplies: Stool Containers - 24, 48, 72 Hour Kit (T291)

Container/Tube: Stool container

Specimen Volume: Entire collection

Collection Instructions:

1. Collect a 24-hour fecal collection.

2. If no specimen is obtained within 24 hours, extend collection time to 48 to 72 hours. Document time frame.

Useful For

Diagnosing protein-losing enteropathies

Profile Information

Test ID Reporting Name Available Separately Always Performed
AATS Alpha-1-Antitrypsin, S No Yes
A1ATF Alpha-1-Antitrypsin, 24 Hr, F No Yes

Method Name


Reporting Name

Alpha-1-Antitrypsin Clearance

Specimen Type


Specimen Minimum Volume

Homogenized feces: 1 mL
Serum: 0.5 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Fecal Frozen (preferred) 14 days
  Ambient  14 days
  Refrigerated  14 days
Serum Frozen (preferred) 28 days
  Ambient  28 days
  Refrigerated  28 days

Reference Values


≤27 mL/24 hours



≤54 mg/dL



100-190 mg/dL

Day(s) Performed

Monday through Friday

Report Available

Same day/1 to 2 days

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Test Classification

This test has been modified from the manufacturer's instructions. Its performance characteristics were determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the US Food and Drug Administration.

CPT Code Information

82103 x 2

LOINC Code Information

Test ID Test Order Name Order LOINC Value
A1AFS Alpha-1-Antitrypsin Clearance 93419-0


Result ID Test Result Name Result LOINC Value
AAT24 Alpha-1-Antitrypsin, 24 Hr, F 9407-8
AATS Alpha-1-Antitrypsin, S 6771-0
CRCLR Clearance 18271-7


If not ordering electronically, complete, print, and send a Gastroenterology and Hepatology Client Test Request (T728) with the specimen.