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Test ID ALDG Autoimmune Liver Disease Panel, Serum


Specimen Required


Container/Tube:

Preferred: Serum gel

Acceptable: Red top

Specimen Volume: 1.5 mL


Useful For

Evaluation of patients with suspected autoimmune liver disease, specifically autoimmune hepatitis or primary biliary cirrhosis

 

Evaluation of patients with liver disease of unknown etiology

Profile Information

Test ID Reporting Name Available Separately Always Performed
AMA Mitochondrial Ab, M2, S Yes Yes
ANA2 Antinuclear Ab, S Yes Yes
SMAS Smooth Muscle Ab Screen, S Yes Yes

Reflex Tests

Test ID Reporting Name Available Separately Always Performed
SMAT Smooth Muscle Ab Titer, S No No

Testing Algorithm

If smooth muscle antibody (SMA) screen is positive then the SMA titer will be performed at an additional charge.

Method Name

AMA: Enzyme Immunoassay (EIA)

SMAS: Indirect Immunofluorescence

ANA2: Enzyme-Linked Immunosorbent Assay (ELISA)

Reporting Name

Autoimmune Liver Disease Panel, S

Specimen Type

Serum

Specimen Minimum Volume

1 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Serum Refrigerated (preferred) 14 days
  Frozen  14 days

Reference Values

SMOOTH MUSCLE ANTIBODIES

Negative

If positive, results are titered.

Reference values apply to all ages.

 

MITOCHONDRIAL ANTIBODIES (M2)

Negative: <0.1 Units

Borderline: 0.1-0.3 Units

Weakly positive: 0.4-0.9 Units

Positive: ≥1.0 Units

Reference values apply to all ages.

 

ANTINUCLEAR ANTIBODIES (ANA2)

Negative: ≤1.0 Units

Weakly positive: 1.1-2.9 Units

Positive: 3.0-5.9 Units

Strongly positive: ≥6.0 Units

Reference values apply to all ages.

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Test Classification

See Individual Test IDs

CPT Code Information

86038

86381

86015

86015-Titer (if appropriate)

LOINC Code Information

Test ID Test Order Name Order LOINC Value
ALDG Autoimmune Liver Disease Panel, S 94700-2

 

Result ID Test Result Name Result LOINC Value
609515 Smooth Muscle Ab Screen, S 26971-2
AMA Mitochondrial Ab, M2, S 51715-1
ANA2 Antinuclear Ab, S 94875-2

Day(s) Performed

Monday through Saturday

Report Available

2 to 3 days