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Test ID ARGAT Argatroban, Ecarin, Plasma

Ordering Guidance

This test measures argatroban only.


This test is not indicated for monitoring low molecular weight heparin (LMWH), unfractionated heparin (UFH), or oral direct anti-Xa inhibitors (eg, apixaban, rivaroxaban). For monitoring oral direct anti-Xa inhibitors, see APIXA / Apixaban, Anti-Xa, Plasma; or RIVAR / Rivaroxaban, Anti-Xa, Plasma.

Necessary Information


Specimen Required

Specimen Type: Platelet-poor plasma

Collection Container/Tube: Light-blue top (3.2% sodium citrate)

Submission Container/Tube: Plastic vial

Specimen Volume: 1 mL

Collection Instructions:

1. Specimen should be collected 2 hours after initiation of continuous infusion of argatroban.

2. For complete instructions, see Coagulation Guidelines for Specimen Handling and Processing.

3. Centrifuge, transfer all plasma into a plastic vial, and centrifuge plasma again.

4. Aliquot plasma into a plastic vial leaving 0.25 mL in the bottom of centrifuged vial.

5. Freeze plasma immediately (no longer than 4 hours after collection) at -20° C or, ideally, below -40° C.

Additional Information:

1. Double-centrifuged specimen is critical for accurate results as platelet contamination may cause spurious results.

2. Each coagulation assay requested should have its own vial.

Useful For

Measuring argatroban concentration in plasma


This assay is not useful for measurement of other direct thrombin inhibitors eg, dabigatran or bivalirudin.

Method Name

Chromogenic Assay

Reporting Name

Argatroban, Ecarin, P

Specimen Type

Plasma Na Cit

Specimen Minimum Volume

0.5 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Plasma Na Cit Frozen 42 days

Reference Values

<0.10 mcg/mL

Day(s) Performed

Monday through Friday

Report Available

1 to 3 days

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Test Classification

This test was developed, and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the US Food and Drug Administration.

CPT Code Information


LOINC Code Information

Test ID Test Order Name Order LOINC Value
ARGAT Argatroban, Ecarin, P 55363-6


Result ID Test Result Name Result LOINC Value
ARGA1 Argatroban, Ecarin, P 55363-6
ARGA2 Interpretation 69049-5
ARGA3 Cautions 62364-5


If not ordering electronically, complete, print, and send a Coagulation Test Request (T753) with the specimen.