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HelpTest ID CLZ Clozapine, Serum
Useful For
Monitoring patient compliance of clozapine treatment
An aid to achieving desired serum levels
Method Name
Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS)
Reporting Name
Clozapine, SSpecimen Type
Serum RedOrdering Guidance
Specimen Required
Supplies: Sarstedt Aliquot Tube, 5 mL (T914)
Collection Container/Tube: Red top (serum gel/SST are not acceptable)
Submission Container/Tube: Plastic vial
Specimen Volume: 1 mL
Collection Instructions:
1. Collect specimen immediately before next scheduled dose.
2. Within 2 hours of collection, centrifuge and aliquot serum into a plastic vial.
Additional Information: Therapeutic range (trough level) applies to specimens collected immediately prior to next dose.
Specimen Minimum Volume
0.6 mL
Specimen Stability Information
| Specimen Type | Temperature | Time |
|---|---|---|
| Serum Red | Refrigerated (preferred) | 28 days |
| Frozen | 28 days | |
| Ambient | 7 days |
Reference Values
Clozapine
Therapeutic range: 350-600 ng/mL
Norclozapine
Therapeutic range: Not well established
Clozapine + Norclozapine
Therapeutic range: Not well established
Day(s) Performed
Monday through Friday
Report Available
3 to 5 daysPerforming Laboratory
Mayo Clinic Laboratories in Rochester
Test Classification
This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.CPT Code Information
80159
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| CLZ | Clozapine, S | 65632-2 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| 33840 | Clozapine | 6896-5 |
| 33841 | Norclozapine | 10992-6 |
| 33842 | Clozapine+Norclozapine Total | 12375-2 |
Forms
If not ordering electronically, complete, print, and send a Therapeutics Test Request (T831) with the specimen.