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Test ID CNSA Central Nervous System Consultation, Autopsy, Varies

Shipping Instructions

Ship specimen using the Central Nervous System Consult Kit (T633).

Necessary Information

It is imperative that detailed clinical information and, when possible, operative notes and radiographs accompany the specimen.

Specimen Required

Hematoxylin-and-eosin stained sections are also acceptable, but must be accompanied by paraffin blocks and/or remaining wet tissue.


In cases submitted as part of a research protocol, contact 507-284-3887 for further guidance.


Supplies: Central Nervous System Consult Kit (T633)

Sources: Brain (and spinal cord when indicated)

Container/Tube: Plastic container

Specimen Volume: 1 cm(3) cube

Collection Instructions:

1. Take a small (1 cm[3]) cube of brain from 1 of the frontal lobes (typically, right inferior frontal).

2. Wrap in aluminum foil and place in plastic container.

3. Label container with identifying information (ie, patient name, date of birth, autopsy number, and date of collection).

4. Freeze and store in a -70° C freezer.

5. Place the remaining brain in 10% formalin if non-Creutzfeldt-Jakob disease (CJD), and 15% formalin for suspected cases of CJD, suspended by a thread under the basilar artery and fixed for 7 to 10 days.

Additional Information: Upon completion of consultation, the brain tissue will be stored 10 years in the Mayo Clinic Tissue Registry. The Mayo Clinic policy precludes our evaluation of cases under litigation that involve non-Mayo Clinic patients.

Useful For

Evaluation of congenital neurological disease


Evaluation of neurodegenerative disease


Evaluation of cases with a complex neurological or neurosurgical history


Evaluation of sudden unexplained death


This test is not intended for cases under litigation without preauthorization.

Reflex Tests

Test ID Reporting Name Available Separately Always Performed
NERPC Necropsy, regional No No
NESPC Necropsy, single organ No No

Testing Algorithm

When only a brain is submitted, NESPC / Necropsy, single organ (Bill Only) will be charged.

When both a brain and spinal cord are submitted, NERPC / Necropsy, regional (Bill Only) will be charged.

Method Name


Reporting Name

Neuropathology Consult

Specimen Type


Specimen Minimum Volume

Entire collection

Specimen Stability Information

Specimen Type Temperature Time Special Container
Varies Ambient (preferred)

Reference Values

An interpretive report will be provided.

Day(s) Performed

Monday through Friday

Report Available

30 to 60 days

Performing Laboratory

Mayo Clinic Laboratories in Rochester

CPT Code Information

88037 (if appropriate)

88036 (if appropriate)

LOINC Code Information

Test ID Test Order Name Order LOINC Value
CNSA Neuropathology Consult 18743-5


Result ID Test Result Name Result LOINC Value
71070 Interpretation 18743-5
71071 Participated in the Interpretation No LOINC Needed
71072 Report electronically signed by 19139-5
71073 Addendum 35265-8
71074 Gross Description 22634-0
71075 Material Received 22633-2
71589 Disclaimer 62364-5
71795 Case Number 80398-1

Test Classification

Not Applicable