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Test ID CPAVP Copeptin proAVP, Plasma

Specimen Required

Patient Preparation: For water-deprived testing, have the patient fast and thirst for at least 8 hours (no liquids, including water, are allowed)

Collection Container/Tube: Lavender top (EDTA)

Submission Container/Tube: Plastic screw-top vial

Specimen Volume: 0.5 mL

Collection Information: Centrifuge and aliquot plasma into plastic vial. Do not submit in original tube.

Useful For

Investigating the differential diagnosis for patients with water balance disorders, including diabetes insipidus, in conjunction with osmolality and hydration status


May aid in the evaluation of cardiovascular disease in conjunction with other cardiac markers

Method Name

Immunofluorescent Assay (IFA)

Reporting Name

Copeptin proAVP, P

Specimen Type

Plasma EDTA

Specimen Minimum Volume

0.3 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Plasma EDTA Refrigerated (preferred) 7 days
  Frozen  30 days
  Ambient  7 days

Reference Values

Non-water deprived, non-fasting adults*: <13.1 pmol/L

Water deprived, fasting adults**: <15.2 pmol/L

Non-water deprived, non-fasting pediatric patients***: <14.5 pmol/L


*Keller T, Tzikas S, Zeller T, et al: Copeptin improves early diagnosis of acute myocardial infarction. J Am Coll Cardiol. 2010 May 11;55[19]:2096-2106. doi: 10.1016/j.jacc.2010.01.029

**In-house Mayo study.

***Du JM, Sang G, Jiang CM, He XJ, Han Y: Relationship between plasma copeptin levels and complications of community-acquired pneumonia in preschool children. Peptides. 2013 Jul;45:61-65. doi: 10.1016/j.peptides.2013.04.015

Day(s) Performed

Monday through Saturday

Report Available

Same day/1 to 3 days

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Test Classification

This test was developed, and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the US Food and Drug Administration.

CPT Code Information


LOINC Code Information

Test ID Test Order Name Order LOINC Value
CPAVP Copeptin proAVP, P 78987-5


Result ID Test Result Name Result LOINC Value
CPAVP Copeptin proAVP, P 78987-5