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Test ID CRHEP Chronic Hepatitis (Unknown Type), Serum


Necessary Information


Date of collection is required.



Specimen Required


Collection Container/Tube: Serum gel

Submission Container/Tube: Plastic vial

Specimen Volume: 3 mL

Collection Instructions:

1. Centrifuge blood collection tube per collection tube manufacturer's instructions (eg, centrifuge and aliquot within 2 hours of collection for BD Vacutainer tubes).

2. Aliquot serum into plastic vial.


Useful For

Diagnosis and evaluation of patients with symptoms of hepatitis with a duration more than 6 months

 

Distinguishing between chronic hepatitis B and chronic hepatitis C

Profile Information

Test ID Reporting Name Available Separately Always Performed
HBC HBc Total Ab, S Yes Yes
HBAB HBs Antibody, S Yes Yes
HBAG HBs Antigen, S Yes Yes
HCVDX HCV Ab w/Reflex to HCV PCR, S Yes Yes

Reflex Tests

Test ID Reporting Name Available Separately Always Performed
HCVQN HCV RNA Detect/Quant, S Yes No
HBGNT HBs Antigen Confirmation, S No No

Testing Algorithm

If hepatitis C virus (HCV) antibody is reactive, then HCV RNA detection and quantification by real-time reverse transcription polymerase chain reaction will be performed at an additional charge.

 

If hepatitis B surface antigen is reactive, then confirmation will be performed at an additional charge.

 

The following algorithms are available:

-Chronic Hepatitis C Treatment and Monitoring Algorithm: Direct Antiviral Antigen (DAA) Combination

-Hepatitis B: Testing Algorithm for Screening, Diagnosis, and Management

-Hepatitis C: Testing Algorithm for Screening and Diagnosis

Method Name

Chemiluminescence Immunoassay (CIA)

Reporting Name

Chronic Hepatitis Profile

Specimen Type

Serum SST

Specimen Minimum Volume

2.75 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Serum SST Frozen (preferred) 28 days
  Refrigerated  5 days

Reference Values

HEPATITIS B SURFACE ANTIGEN:

Negative

 

HEPATITIS B SURFACE ANTIBODY, QUALITATIVE/QUANTITATIVE

Hepatitis B Surface Antibody

Unvaccinated: Negative

Vaccinated: Positive

 

Hepatitis B Surface Antibody, Quantitative

Unvaccinated: <5.0 mIU/mL

Vaccinated: ≥12.0 mIU/mL

 

HEPATITIS B CORE TOTAL ANTIBODIES:

Negative

 

HEPATITIS C ANTIBODY:

Negative

 

Interpretation depends on clinical setting. See Viral Hepatitis Serologic Profiles.

Day(s) Performed

Monday through Saturday

Report Available

Same day/1 to 2 days

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Test Classification

This test has been cleared, approved, or is exempt by the US Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.

CPT Code Information

86704

86706

86803

87340

87341 (if appropriate)

87522 (if appropriate)

LOINC Code Information

Test ID Test Order Name Order LOINC Value
CRHEP Chronic Hepatitis Profile 92889-5

 

Result ID Test Result Name Result LOINC Value
HCVA4 HCV Ab, S 40726-2
H_BAG HBs Antigen, S 5196-1
HBC HBc Total Ab, S 13952-7
HB_AB HBs Antibody, S 10900-9
HBSQN HBs Antibody, Quantitative, S 5193-8

Forms

If not ordering electronically, complete, print, and send 1 of the following:

-Gastroenterology and Hepatology Client Test Request (T728)

-Infectious Disease Serology Test Request (T916)