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Test ID CSFME Meningitis/Encephalitis Pathogen Panel, PCR, Spinal Fluid

Ordering Guidance

It is not usually recommended that the following tests be concomitantly ordered if this test is ordered:

-LCMV / Cytomegalovirus (CMV), Molecular Detection, PCR, Varies

-LENT / Enterovirus, Molecular Detection, PCR, Varies

-HSVC / Herpes Simplex Virus (HSV), Molecular Detection, PCR, Spinal Fluid

-HHV6V / Human Herpesvirus-6, Molecular Detection, PCR, Spinal Fluid

-LVZV / Varicella-Zoster Virus, Molecular Detection, PCR, Varies


For recommended testing to be ordered with this test, see Additional Testing Requirements.

Additional Testing Requirements

1. In some cases, there may be local public health requirements that impact Mayo Clinic Laboratories’ (MCL) clients and require additional testing on specimens with positive results from this panel. Clients should familiarize themselves with local requirements. MCL recommends that clients retain an aliquot of each specimen submitted for this test to perform additional testing, as needed.

2. It is recommended that the following testing be ordered with this test:

-CCCF / Cell Count and Differential, Spinal Fluid

-TPSF / Protein, Total, Spinal Fluid

-GLSF / Glucose, Spinal Fluid

-GEN / Bacterial Culture, Aerobic, Varies

-GRAM / Gram Stain, Varies

3. If clinically indicated, the following testing should also be ordered with this test:

-FS / Fungal Smear, Varies

-FGEN / Fungal Culture, Routine

-LFACX / Cryptococcus Antigen with Reflex, Spinal Fluid

Shipping Instructions

Specimen must arrive at refrigerated temperature within 7 days of collection.

Necessary Information

Specimen source is required.

Specimen Required

Specimen Type: Spinal fluid

Container/Tube: Sterile vial

Specimen Volume: 1 mL

Collection Instructions: Frozen specimens are not acceptable.

Useful For

Rapid detection of meningitis and encephalitis caused by:

-Escherichia coli K1 (K1 serotype only)

-Haemophilus influenzae

-Listeria monocytogenes

-Neisseria meningitidis (encapsulated strains only)

-Streptococcus agalactiae (Group B Strep)

-Streptococcus pneumoniae

-Cytomegalovirus (CMV)


-Herpes simplex virus 1 (HSV-1)

-Herpes simplex virus 2 (HSV-2)

-Herpes simplex virus 6 (HHV-6)

-Human parechovirus

-Varicella zoster virus (VZV)

-Cryptococcus neoformans/gattii


This test is not intended for use with cerebrospinal fluid (CSF) collected from indwelling medical devices (eg, CSF shunts).


This test is not recommended as a test of cure.

Testing Algorithm

For more information see Meningitis/Encephalitis Panel Algorithm

Method Name

Multiplex Polymerase Chain Reaction (PCR)

Reporting Name

Meningitis Encephalitis Panel, PCR

Specimen Type


Specimen Minimum Volume

0.5 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
CSF Refrigerated 7 days

Reference Values

Negative (for all targets)

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Test Classification

This test has been cleared, approved, or is exempt by the US Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.

CPT Code Information


LOINC Code Information

Test ID Test Order Name Order LOINC Value
CSFME Meningitis Encephalitis Panel, PCR 82180-1


Result ID Test Result Name Result LOINC Value
SRCSF Specimen Source 31208-2
42375 Escherichia coli K1 82182-7
42376 Haemophilus influenzae 82183-5
42377 Listeria monocytogenes 82184-3
42378 Neisseria meningitidis 82185-0
42379 Streptococcus agalactiae 82186-8
42380 Streptococcus pneumoniae 82187-6
42381 Cytomegalovirus 82189-2
42382 Enterovirus 82194-2
42383 Herpes Simplex Virus 1 82190-0
42384 Herpes Simplex Virus 2 82191-8
42385 Human Herpes Virus 6 82192-6
42386 Human Parechovirus 82193-4
42387 Varicella Zoster Virus 82188-4
42388 Cryptococcus neoformans/gattii 82181-9
605190 Interpretation 59464-8

Day(s) Performed

Monday through Sunday

Report Available

1 to 2 days