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Test ID CYCPK Cyclosporine, Peak, Blood

Useful For

Monitoring whole blood peak cyclosporine concentration during therapy, particularly in individuals coadministered cytochrome P450 (CYP) 3A4 substrates, inhibitors, or inducers


Adjusting dose to optimize immunosuppression while minimizing toxicity


Evaluating patient compliance

Method Name

Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)

Reporting Name

Cyclosporine, Peak, B

Specimen Type

Whole Blood EDTA

Necessary Information

Date of last dose, time of last dose, and dosage information are required.

Specimen Required

Container/Tube: Lavender top (EDTA)

Specimen Volume: 3 mL

Collection Instructions:

1. Do not centrifuge.

2. Send whole blood specimen in original tube. Do not aliquot.

Additional Information: No definitive therapeutic or toxic ranges have been established for this peak testing.

Specimen Minimum Volume

1 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Whole Blood EDTA Refrigerated (preferred) 14 days
  Ambient  14 days
  Frozen  14 days

Reference Values

No definitive therapeutic or toxic ranges have been established.


Optimal blood drug levels are influenced by type of transplant, patient response, time posttransplant, coadministration of other drugs, and drug formulation.


The following 2-hour postdose cyclosporine ranges are only suggested guidelines:

Kidney transplant: 800-1700 ng/mL

Liver transplant: 600-1000 ng/mL


Target steady-state peak concentrations vary depending on the type of transplant, concomitant immunosuppression, clinical/institutional protocols, and time posttransplant. Results should be interpreted in conjunction with this clinical information and any physical signs/symptoms of rejection/toxicity.

Day(s) Performed

Monday through Sunday

Report Available

2 to 4 days

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Test Classification

This test was developed, and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the US Food and Drug Administration.

CPT Code Information


LOINC Code Information

Test ID Test Order Name Order LOINC Value
CYCPK Cyclosporine, Peak, B 53834-8


Result ID Test Result Name Result LOINC Value
42398 Cyclosporine, Peak, B 53834-8
DATEC Date of last dose 29742-4
TIMEC Time of last dose 29637-6
DOSEC Dose, mg 4207-7


If not ordering electronically, complete, print, and send 1 of the following forms with the specimen:

-Renal Diagnostics Test Request (T830)

-Therapeutics Test Request (T831)