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Test ID DEXA Dexamethasone, Serum

Ordering Guidance

To detect the metabolite of fluticasone or Flonase, order 17BFP / Fluticasone 17-Beta-Carboxylic Acid, Random, Urine.


For synthetic glucocorticoid analyte screen, order SGSS / Synthetic Glucocorticoid Screen, Serum.

Specimen Required

Collection Container/Tube:

Preferred: Red top

Acceptable: Serum gel

Submission Container/Tube: Plastic vial

Specimen Volume: 2 mL

Collection Instructions:

1. Draw blood between 7:30 a.m. and 9:00 a.m. the morning following an evening dose.

2. Centrifuge and aliquot serum into plastic vial within one hour of collection.

Useful For

Confirming the presence of dexamethasone in serum


Confirming the cause of secondary adrenal insufficiency


This test is not useful as the sole basis for a diagnosis or treatment decisions.

Method Name

Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)

Reporting Name

Dexamethasone, S

Specimen Type


Specimen Minimum Volume

0.6 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Serum Frozen (preferred) 28 days
  Refrigerated  7 days
  Ambient  72 hours

Reference Values

Baseline: <30 ng/dL

8:00 a.m. following 1 mg Dexamethasone, previous evening: >100 ng/dL

8:00 a.m. following 8 mg Dexamethasone, (4 x 2 mg doses) previous day: >800 ng/dL

Day(s) Performed

Tuesday, Thursday

Report Available

2 to 5 days

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Test Classification

This test was developed, and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the US Food and Drug Administration.

CPT Code Information


LOINC Code Information

Test ID Test Order Name Order LOINC Value
DEXA Dexamethasone, S 14062-4


Result ID Test Result Name Result LOINC Value
609439 Dexamethasone, S 14062-4