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Test ID EMAIG Endomysial Antibodies, IgG, Serum

Ordering Guidance

Cascade testing is recommended for celiac disease. Cascade testing ensures that testing proceeds in an algorithmic fashion. The following cascade tests are available; select the appropriate one for your specific patient situation.

-For complete testing including human leukocyte antigen (HLA) DQ, order CDCOM / Celiac Disease Comprehensive Cascade, Serum and Whole Blood

-For complete testing excluding HLA DQ, order CDSP / Celiac Disease Serology Cascade, Serum

-For patients already adhering to a gluten-free diet, order CDGF / Celiac Disease Gluten-Free Cascade, Serum and Whole Blood


To order individual tests, see Celiac Disease Diagnostic Testing Algorithm in Special Instructions.

Specimen Required

Collection Container/Tube:

Preferred: Serum gel

Acceptable: Red top

Submission Container/Tube: Plastic vial

Specimen Volume: 2 mL

Useful For

Analysis of IgG-endomysial antibodies for the diagnosis of dermatitis herpetiformis and celiac disease


Monitoring adherence to gluten-free diet in patients with dermatitis herpetiformis and celiac disease

Reflex Tests

Test ID Reporting Name Available Separately Always Performed
EMAGT EMA Titer (IgG), S No No

Testing Algorithm

If the IgG-endomysial antibodies result is positive or indeterminate, then the antibody titer will be performed at an additional charge.


The following algorithms are available:

-Celiac Disease Comprehensive Cascade Test Algorithm

-Celiac Disease Diagnostic Testing Algorithm

-Celiac Disease Gluten-Free Cascade Test Algorithm

-Celiac Disease Routine Treatment Monitoring Algorithm

-Celiac Disease Serology Cascade Test Algorithm

Method Name

Indirect Immunofluorescence Assay (IFA)

Reporting Name

Endomysial Abs (IgG), S

Specimen Type


Specimen Minimum Volume

0.5 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Serum Refrigerated (preferred) 14 days
  Frozen  30 days
  Ambient  14 days

Reference Values

Negative in normal individuals; also negative in patients with either dermatitis herpetiformis or celiac disease while adhering to gluten-free diet.

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Test Classification

This test has been modified from the manufacturer's instructions. Its performance characteristics were determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the US Food and Drug Administration.

CPT Code Information


86231-titer (if appropriate)

LOINC Code Information

Test ID Test Order Name Order LOINC Value
EMAIG Endomysial Abs (IgG), S 39554-1


Result ID Test Result Name Result LOINC Value
608880 Endomysial IgG Ab, S 39554-1

Day(s) Performed

Monday through Friday

Report Available

2 to 7 days


If not ordering electronically, complete, print, and send a Gastroenterology and Hepatology Client Test Request (T728) with the specimen.