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Test ID FFCAH Congenital Adrenal Hyperplasia (CAH) Pediatric Profile 6, Comprehensive Screen


Specimen Required


Specimen Type: Serum

Container/Tube: Red

Specimen Volume: 3.5 mL

Collection Instructions: Draw blood in a plain, red-top tube(s). (Serum gel tube is not acceptable.) Spin down and separate within 1 hour of collection and send 3.5 mL of serum frozen in plastic vial.


Method Name

High Pressure Liquid Chromatography/Tandem Mass

Spectrometry (HPLC/MS-MS)

Reporting Name

CAH Profile 6

Specimen Type

Serum Red

Specimen Minimum Volume

2 mL NOTE: Minimum volume does not allow for repeat analysis.

Specimen Stability Information

Specimen Type Temperature Time Special Container
Serum Red Frozen 90 days

Reference Values

Androstenedione

 

Units:  ng/dL

 

Age              

Range

Premature (26-28w) Day 4    

63 - 935

Premature (31-35w) Day 4    

50 - 449

Full Term (1-7 days)                  

<10 - 279

 

Levels decrease rapidly to <52 ng/dL after one week.

 

 

1 - 11m

<10 - 37

 

Androstenedione gradually decreases during the first six months to prepubertal levels.

 

 

Prepubertal Children         

<10 - 17

Adult Males                          

44 - 186

Adult Females                    

28 - 230

Females Postmenopausal         

<10-93

 

 

 

Cortisol

 

Units:  ug/dL

 

Age

Range

Premature (26-28w) Day 4     

1.0 - 11

Premature (31-35w) Day 4     

2.5 -   9.1

Full Term Day 3                 

1.7 - 14

Full Term Day 7                           

2.0 - 11

31d - 11m

2.8 - 23

12m - 15y (8:00 AM)

3 .0 - 21

 

 

Adults

 

8:00 AM                   

8.0 - 19

4:00 PM                   

4.0 - 11

 

 

 

Deoxycorticosterone (DOC)

 

Units:  ng/dL

 

Age

Range

Premature (26 - 28w) Day 4         

20 - 105

Premature (34 - 36w) Day 4         

28 - 78

 

Newborn:  Levels are markedly elevated at birth and decrease rapidly during the first week to the range of 7 - 49 as found in older infants.

 

 

1 - 11m

7 - 49

Prepubertal Children  

2 - 34

Pubertal Children and Adults 8:00 AM                

2 - 19

 

 

 

Dehydroepiandrosterone (DHEA)

Units:  ng/dL

 

Age

Range

Premature (26 - 31w)                

82 - 1484

Premature (32 - 35w)

56 - 1853

Full Term (2 - 7d)

41 - 1292

8d - 5m

<948

6 - 12m

<136

1 - 5 y

<68

6 - 7 y

<111

8 - 10 y

<186

11 - 12 y

<202

13 - 14 y

<319

15 - 16 y

39 - 481

17 - 19 y          

40 - 491

20 - 49 y          

31 - 701

≥ 50 y

21 - 402      

 

 

 

11-Desoxycortisol

 

Units:  ng/dL

 

Age

Range

Premature (26-28w) Day 4

110 - 1376

Premature (31-35w) Day 4

48 - 579

Newborn Day 3     

13 - 147

1 - 11m

<10 - 156

Prepubertal 8:00 AM                     

20 - 155

Pubertal Children and Adults 8:00 AM           

12 - 158

 

 

 

17-OH Pregnenolone

 

Units:  ng/dL

 

Age

Range

Premature (26-28w) Day 4

375 - 3559

Premature (31-35w) Day 4

64 - 2380

3 Days

10 - 829

1 - 5m

36 - 763

6 - 11m

42 - 540

12 - 23m

14 - 207

24m  - 5y

10 - 103

6 - 9y

10 - 186

Pubertal

44 - 235

Adults

53 - 357

 

 

 

Progesterone

 

Units:  ng/dL

 

Males

 

Age

Range                    

1 - 16y

<10 - 15

Adults  

<10 - 11

 

 

Females

 

Age

Range                    

1-10y

<10 - 26

11y

<10 - 255

12y                                    

<10 - 856

13y

<10 - 693

14y

<10 - 1204

15y

<10 - 1076

16y

<10 -1294

 

 

Adult

 

Cycle Days

Range

1 - 6

<10 - 17

7 - 12

<10 - 135

13 - 15

<10 - 1563

16 - 28

<10 - 2555

Post Menopausal

<10

 

 

Note: Luteal progesterone peaked from 350 to 3750 ng/dL on days ranging from 17 to 23.

 

 

 

17-Alpha-Hydroxyprogesterone 17-OHP

 

Units:  ng/dL    

 

Age

Range            

Premature (26-28w) Day 4

124 - 841

Premature (31-35w) Day 4

26 - 568

Full-Term Day 3

<78

 

 

Males: Levels increase after the first week to peak values ranging from 40 - 200 between 30 and 60 days. Values then decline to a prepubertal value of <91 before one year.

 

 

Prepubertal              

<91

Adult Males                    

27 - 199

 

 

Females

 

1 - 11m

13 - 106

Prepubertal

<91

Adult Females

 

Follicular                     

15-70

Luteal                             

35-290

                          

 

 

Testosterone, Total

 

 

Units:  ng/dL         

 

 

Age

Range

 

Males                                 

 

 

Premature (26-28w) Day 4  

59 - 125

 

Premature (31-35w) Day 4

37 - 198

 

Newborns

75 - 400

 

 

 

 

1 - 7m:  Levels decrease rapidly the first week to 20 - 50, then increase to 60 - 400 between 20 - 60 days. Levels then decline to prepubertal range levels of <2.5 - 10 by seven months.

 

 

 

Females

 

 

Premature (26 - 28w) Day 4

5 - 16

 

Premature (31 - 35w) Day 4

5 - 22

 

Newborns

20 - 64

 

 

 

 

1 - 7m: Levels decrease during the first month to less than 10 and remain there until puberty.

 

 

 

Prepubertal Males and Females    

<2.5 - 10

 

Adult Males  >18 years                

264 - 916

 

Adult Females

 

 

Premenopausal

10 - 55

 

Postmenopausal

7 - 40

 

 

 

 

Males

 

 

Tanner Stage           

Age (years)             

Male

1

<9.8                

<2.5 - 10

2

9.8 - 14.5       

18 - 150

3

10.7 - 15.4        

100 - 320

4

11.8 - 16.2         

200 - 620

5

12.8 - 17.3          

350 - 970

 

 

 

Females

 

 

Tanner Stage          

Age (years)             

Female

1

<9.2               

<2.5 - 10

2

9.2 - 13.7                

7 - 28

3

10.0 - 14.4               

15 - 35

4

10.7 - 15.6               

13 - 32

5

11.8 - 18.6                

20 - 38

Day(s) Performed

Monday, Wednesday

Report Available

10 to 19 days

Performing Laboratory

Esoterix Endocrinology

CPT Code Information

82633/DOC

82634/ 11-Desoxycortisol

82157/Androstenedione

82533/Cortisol

82626/DHEA

84143/17-OH-Pregnenolone

84144/Progesterone

83498/17-OH-Progesterone

84403/Testosterone

LOINC Code Information

Test ID Test Order Name Order LOINC Value
FFCAH CAH Profile 6 Not Provided

 

Result ID Test Result Name Result LOINC Value
Z5043 Cortisol 2143-6
Z5044 Deoxycorticosterone (DOC) 1656-8
Z5045 11-Desoxycortisol 1657-6
Z5046 Dehydroepiandrosterone (DHEA) 2193-1
Z5047 17-OH Pregnenolone 6765-2
Z5048 Progesterone 2839-9
Z5049 17-Alpha-Hydroxyprogesterone 17-OHP 1668-3
Z5050 Androstenedione 1854-9
Z5051 Testosterone, Total 2986-8

Test Classification

This test was developed and its performance characteristics determined by LabCorp. It has not been cleared or approved by the Food and Drug Administration.