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Test ID FFMSS Maternal Serum Screening, Integrated, Specimen #1, PAPP-A, NT

Specimen Required

Specimen #1 collection must occur between 10 weeks, 0 days and 13 weeks, 6 days gestation. (If gestational age is based on Crown-Rump length (CRL), the specimen must be collected when the CRL is between 32.4 - 83.9 mm)


Draw blood in a plain red-top tube(s), serum gel tube is acceptable. Spin down and send 0.5 mL serum refrigerated in a plastic vial.


Separate from cells ASAP or within 2 hours of collection.



Submit with order: Patient's date of birth, current weight, number of fetuses present, patient's race, if the patient was diabetic at the time of conception, if there is a known family history of neural tube defects, if the patient has had a previous pregnancy with a trisomy, if the patient is currently smoking, if the patient is taking valproic acid or carbamazepine (Tegretol), if this is a repeat sample, and the age of the egg donor if in vitro fertilization.


In addition to the above:

If a NT measurement is performed: the date of ultrasound, the CRL measurement, the nuchal translucency (NT) measurement and the name and certification number of the sonographer is required. NT must be measured when the CRL is between 38-83.9mm.




If no NT measurement is performed: a due date or CRL measurement with the date of ultrasound is required.


The NT measurement must also be performed by an ultrasonographer that is certified by one of the following agencies: Fetal Medicine Foundation (FMF) or Nuchal Translucency Quality Review (NTQR).

Useful For

Helpful to identify pregnancies at increased risk of having a child with Down Syndrome (DS), open neural tube defects (ONTD) and trisomy 18 (T18). This test is not diagnostic.

Profile Information

Test ID Reporting Name Available Separately Always Performed
FPATI Patient Information No Yes
FMAS1 Maternal Screen INT-1 No Yes

Method Name

Quantitative Chemiluminescent Immunoassay

Reporting Name

Maternal Serum Screen INT, Sp-1

Specimen Type


Specimen Minimum Volume

0.3 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Serum Refrigerated (preferred) 14 days
  Frozen  90 days
  Ambient  72 hours

Reference Values

An interpretive report will be provided.


Part 2 must be completed in order to receive an interpretable result.


If the second specimen is not received for sequential screening, the results are uninterpretable and no maternal risk will be provided.

Performing Laboratory

ARUP Laboratories

CPT Code Information


LOINC Code Information

Test ID Test Order Name Order LOINC Value
FFMSS Maternal Serum Screen INT, Sp-1 Not Provided


Result ID Test Result Name Result LOINC Value
Z5958 PAPP-A Maternal 48407-1
Z5959 Nuchal Translucency (NT) 12146-7
Z5960 Nuchal Translucency (NT), Twin B 12146-7
Z5961 Maternal Screen Interpretation 49586-1
Z5962 Maternal Age At Delivery 21612-7
Z5963 Maternal Weight 29463-7
Z5964 Estimated Due Date 11778-8
Z5965 Gestational Age Calculated at Coll. 18185-9
Z5966 Dating 21299-3
Z5967 Number of Fetuses 11878-6
Z5968 Maternal Race 21484-1
Z5969 Smoking 64234-8
Z5970 Family History of Aneuploidy 32435-0
Z5971 Specimen 19151-0
Z5972 Crown Rump Length 11957-8
Z5973 Crown Rump Length, Twin B 11957-8
Z5974 Sonographer Certification Number 49089-6
Z5975 Sonographer Name 49088-8
Z5976 Ultrasound Date 34970-4
Z5977 Best date to draw sample nmb 2 by 33882-2
Z5978 EER Maternal Serum, Integrated, Sp1 11526-1

Day(s) Performed

Sunday through Saturday

Report Available

6 to 10 days