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Test ID FHLCG Immunoglobulin G (IgG) Heavy and Light Chain (HLC) Pairs, Kappa and Lambda with Ratio

Specimen Required

Specimen Type: Serum

Container/Tube:  Red top or SST

Specimen Volume: 0.75 mL

Collection Instructions: Draw blood in a plain red-top tube, serum gel tube(s) is also acceptable. Separate serum immediately after coagulation (30 minutes) to prevent hemolysis. Send 0.75 mL of serum refrigerated in a plastic vial.


NOTE: Patient should be fasting for eight hours to avoid lipemic sample interference.

Useful For

Heavy and light chain pair quantitation may be useful for:

1. Distinguishing between broadly migrating monoclonal proteins and restricted polyclonal immunoglobulin patterns on serum electrophoresis. 

2. Quantitating monoclonal IgG proteins that are difficult to quantitate using serum protein electrophoresis alone.

3. Providing a more specific quantitation of the monoclonal protein than total IgG measurements alone.

Method Name


Reporting Name

IgG Heavy Light Chains (HLC), S

Specimen Type


Specimen Stability Information

Specimen Type Temperature Time Special Container
Serum Refrigerated (preferred) 14 days
  Ambient  14 days
  Frozen  14 days

Reference Values

IgG Kappa (g/L): 4.03 - 9.78

IgG Lambda (g/L): 1.97 - 5.71

IgG Kappa:IgG Lambda ratio: 0.98 - 2.75

Day(s) Performed

Tuesday, Friday

Report Available

1 to 9 days

Performing Laboratory

LabCorp Burlington

CPT Code Information

83883 x 2

LOINC Code Information

Test ID Test Order Name Order LOINC Value
FHLCG IgG Heavy Light Chains (HLC), S 74773-3


Result ID Test Result Name Result LOINC Value
Z5613 IgG Kappa, S 74862-4
Z5614 IgG Lambda, S 74863-2
Z5615 IgG K/L HLC Ratio 74868-1

Specimen Minimum Volume

0.5 mL