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Test ID FLCS Immunoglobulin Free Light Chains, Serum

Specimen Required

Collection Container/Tube:

Preferred: Serum gel

Acceptable: Red top

Submission Container/Tube: Plastic vial

Specimen Volume: 1 mL

Collection Instructions: Centrifuge and aliquot serum into a plastic vial.

Useful For

Monitoring serum from patients with monoclonal light chain diseases without a M-spike on protein electrophoresis


May be useful as a diagnostic test in patients in whom there is a suspicion of primary systemic amyloidosis, light chain deposition disease, or non-secretory myeloma

Profile Information

Test ID Reporting Name Available Separately Always Performed
KFLCS Kappa Free Light Chain, S No Yes
LFLCS Lambda Free Light Chain, S No Yes
KLRS Kappa/Lambda FLC Ratio No Yes

Testing Algorithm

The following algorithms are available:

-Amyloidosis: Laboratory Approach to Diagnosis

-Multiple Myeloma: Laboratory Screening

Method Name


Reporting Name

Immunoglobulin Free Light Chains, S

Specimen Type


Specimen Minimum Volume

0.5 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Serum Refrigerated (preferred) 28 days
  Frozen  28 days
  Ambient  72 hours

Reference Values


0.33-1.94 mg/dL



0.57-2.63 mg/dL




Performing Laboratory

Mayo Clinic Laboratories in Rochester

Test Classification

This test has been cleared, approved, or is exempt by the US Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.

CPT Code Information

83521 x 2

LOINC Code Information

Test ID Test Order Name Order LOINC Value
FLCS Immunoglobulin Free Light Chains, S In Process


Result ID Test Result Name Result LOINC Value
LFLCS Lambda Free Light Chain, S 33944-0
KLRS Kappa/Lambda FLC Ratio 48378-4
KFLCS Kappa Free Light Chain, S 36916-5

Day(s) Performed

Monday through Friday

Report Available

Same day/1 to 2 days


If not ordering electronically, complete, print, and send 1 of the following forms with the specimen: 

-General Request (T239)

-Hematopathology/Cytogenetics Test Request (T726)

-Cardiovascular Test Request (T724)