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Test ID FMSS2 Maternal Serum Screening, Integrated, Specimen #2, Alpha Fetoprotein, Hcg, Estriol, and Inhibin A

Specimen Required

Specimen must be drawn between 14 weeks, 0 days and 24 weeks, 6 days gestation (based on the CRL). Recommended time for maternal serum screening is 16 to 18 weeks gestation. Acceptable date ranges to draw the second samples will be provided in the Integrated-1 report.


Draw blood in a plain red-top tube(s), serum gel tube is acceptable. Spin down and send 3 mL of serum refrigerated in a plastic vial.


Separate from cells ASAP or within 2 hours of collection.


This test requires that a previous first trimester specimen, Maternal Serum Screening, Integrated, Specimen #1, PAPP-A, NT (ARUP test ID: 3000147), has been performed.

Useful For

Helpful to identify pregnancies at increased risk of having a child with Down syndrome (trisomy 21), Open Neural Tube Defect (ONTD, spina bifida) and trisomy 18 (T18). This test is not diagnostic.

The patient information provided with the Integrated, Specm1 will be used to calculate the risks for this report.

Method Name

Quantitative Chemiluminescent Immunoassay

Reporting Name

Maternal Serum Screen INT, Sp-2

Specimen Type


Specimen Minimum Volume

1 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Serum Refrigerated (preferred) 14 days
  Frozen  365 days
  Ambient  72 hours

Reference Values

An interpretive report will be provided.

Day(s) Performed

Sunday - Saturday

Report Available

2 to 8 days

Performing Laboratory

ARUP Laboratories

CPT Code Information


LOINC Code Information

Test ID Test Order Name Order LOINC Value
FMSS2 Maternal Serum Screen INT, Sp-2 Not Provided


Result ID Test Result Name Result LOINC Value
Z5170 Patient's AFP 1834-1
Z5171 MoM for AFP 20450-3
Z5172 Patient's uE3 2250-9
Z5173 MoM for uE3 20466-9
Z5174 Patient's hCG, 2nd Trimester 19080-1
Z5175 hCG MoM, 2nd Trimester 20465-1
Z5176 Patient's DIA 23883-2
Z5177 MoM for DIA 35738-4
Z5178 PAPP-A Maternal 32046-5
Z5179 MoM for PAPP-A 32123-2
Z5180 Nuchal Translucency (NT) 12146-7
Z5181 MoM for NT 49035-9
Z5182 Nuchal Translucency (NT), Twin B 12146-7
Z5183 MoM for NT, Twin B 49035-9
Z5184 Maternal Screen Interpretation 49586-1
Z5185 Maternal Age At Delivery 21612-7
Z5186 Maternal Weight 29463-7
Z5187 Estimated Due Date 11778-8
Z5188 Gestational Age for Second Specimen 18185-9
Z5189 Dating 21299-3
Z5190 Number of Fetuses 11878-6
Z5191 Maternal Race 21484-1
Z5192 Insulin Req Maternal Diabetes 44877-9
Z5193 Smoking 64234-8
Z5194 Family Hx Neural Tube Defect 8670-2
Z5195 Family History of Aneuploidy 32435-0
Z5196 Specimen 19151-0
Z5197 Crown Rump Length 11957-8
Z5198 Crown Rump Length, Twin B 11957-8
Z5199 Sonographer Certification Number 49089-6
Z5200 Sonographer Name 49088-8
Z5201 Ultrasound Date 34970-4
Z5202 EER Maternal Serum, Integrated, Sp2 11526-1