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Test ID HITIG Heparin-PF4 IgG Antibody, Serum

Useful For

Detection of IgG antibodies directed against heparin/platelet factor 4 complexes that are implicated in the pathogenesis of immune-mediated type II heparin-induced thrombocytopenia, spontaneous heparin platelet-factor 4 IgG antibody, and thrombocytopenia and thrombosis occurring after severe acute respiratory syndrome coronavirus 2 adenovirus vector vaccine

Method Name

Enzyme-Linked Immunosorbent Assay (ELISA)

Reporting Name

Heparin-PF4 IgG Ab (HIT), S

Specimen Type

Serum Red

Specimen Required

Patient Preparation: Fasting is preferred but not required 

Collection Container/Tube: Red top 

Submission Container/Tube: Plastic vial 

Specimen Volume: 1 mL 

Collection Instructions: Centrifuge and aliquot serum into a plastic vial. 

Specimen Stability Information: Frozen (preferred) 2 years/Refrigerate 7 days 

Specimen Minimum Volume

0.5 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Serum Red Frozen (preferred)
  Refrigerated  7 days

Reference Values




HIT Interpretation:


Day(s) Performed

Monday through Sunday

Report Available

1 to 3 days

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Test Classification

This test has been modified from the manufacturer's instructions. Its performance characteristics were determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the US Food and Drug Administration.

CPT Code Information


LOINC Code Information

Test ID Test Order Name Order LOINC Value
HITIG Heparin-PF4 IgG Ab (HIT), S In Process


Result ID Test Result Name Result LOINC Value
46915 HIT ELISA 73818-7
21468 Heparin Inhibition 73817-9
21469 HIT Interpretation 73819-5
21470 HIT Comment 73816-1