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Test ID HMGCR 3-Hydroxy-3-Methylglutaryl Coenzyme-A (HMG-CoA) Reductase, Serum

Ordering Guidance

NMS1 / Necrotizing Myopathy Evaluation, Serum is the preferred first tier test for identification of antibodies specific for necrotizing autoimmune myopathy (HMGCOA-IgG and SRP-IgG). This initial evaluation includes signal recognition particle (SRP) antibodies performed using tissue indirect immunofluorescence, which increases the clinical sensitivity as compared to SRP immunoblot methodologies.

Specimen Required

Collection Container/Tube: 

Preferred: Red top 

Acceptable: Serum gel 

Submission Container/Tube: Plastic vial 

Specimen Volume: 2 mL 

Collection Instructions: Centrifuge and aliquot serum into a plastic vial. 

Useful For

Evaluating patients with suspected necrotizing autoimmune myopathy


Measuring 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) antibodies

Method Name

Chemiluminescence Immunoassay (CIA)

Reporting Name

HMG-CoA Reductase Ab, S

Specimen Type


Specimen Minimum Volume

1 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Serum Refrigerated (preferred) 28 days
  Frozen  28 days
  Ambient  72 hours

Reference Values

<20.0 CU

Day(s) Performed

Monday through Friday

Report Available

2 days

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Test Classification

This test has been cleared, approved, or is exempt by the US Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.

CPT Code Information


LOINC Code Information

Test ID Test Order Name Order LOINC Value
HMGCR HMG-CoA Reductase Ab, S 93493-5


Result ID Test Result Name Result LOINC Value
607414 HMG-CoA Reductase Ab, S 93493-5