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Test ID HPFRP Helicobacter pylori with Clarithromycin Resistance Prediction, Molecular Detection, PCR, Feces

Ordering Guidance

Confirmation of eradication testing should not be ordered until 4 or more weeks after cessation of treatment.

Specimen Required

The high sensitivity of amplification by polymerase chain reaction requires the specimen to be processed in an environment in which contamination of the specimen by Helicobacter pylori DNA is unlikely.


Patient Preparation: Proton pump inhibitors and bismuth compounds should be avoided for 2 weeks prior to testing; antibiotics should be avoided for 4 weeks prior to testing.

Supplies: Culture and Sensitivity Stool Transport Vial (T058)

Specimen Type: Preserved feces

Submission Container/Tube: Commercially available transport system specific for recovery of enteric pathogens from fecal specimens (15 mL of nonnutritive transport medium containing phenol red as a pH indicator, either Cary-Blair or Para-Pak C and S)

Specimen Volume: 5 mL

Collection Instructions:

1. Collect fresh fecal specimen and submit 1 gram or 5 mL in container with transport medium.

2. Place feces in preservative within 2 hours of collection.

3. Place vial in a sealed plastic bag and send ambient or refrigerated. Specimens sent frozen will be rejected.

Useful For

Aiding in the diagnosis of Helicobacter pylori infection and prediction of clarithromycin resistance or susceptibility directly from stool

Testing Algorithm

For more information see Helicobacter pylori Diagnostic Algorithm.

Method Name

Real-Time Polymerase Chain Reaction (PCR)

Reporting Name

H pylori + Clarithro Resist, PCR, F

Specimen Type


Specimen Minimum Volume

1 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Fecal Ambient (preferred) 7 days
  Refrigerated  7 days

Reference Values

Not detected

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Test Classification

This test was developed, and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the US Food and Drug Administration.

CPT Code Information


LOINC Code Information

Test ID Test Order Name Order LOINC Value
HPFRP H pylori + Clarithro Resist, PCR, F 88509-5


Result ID Test Result Name Result LOINC Value
HPSRC Specimen Source 31208-2
608002 Helicobacter pylori Result 91061-2
608003 Clarithromycin Resistance Result 88509-5

Day(s) Performed

Monday through Friday

Report Available

4 to 6 days


If not ordering electronically, complete, print, and send one of the following with the specimen:

1. Microbiology Test Request (T244)

2. Gastroenterology and Hepatology Client Test Request (T728)