Test ID HVCOP HIV-1 and HIV-2 Antigen and Antibody Routine Screen, Plasma
Ordering Guidance
If specimen is from either autopsy or cadaver blood sources, the proper FDA-licensed assay is HV1CD / HIV-1 and HIV-2 Antibodies for Cadaveric or Hemolyzed Specimens, Serum.
Screening, supplemental or confirmatory serologic tests for HIV-1 or HIV-2 antibodies cannot distinguish between active neonatal HIV infection and passive transfer of maternal HIV antibodies in infants during the postnatal period (up to 2 years old). Diagnosis of HIV infection in newborns and infants up to 2 years old should be made by virologic tests, such as detection of HIV-1 DNA and RNA (HIVP / HIV-1 DNA and RNA Qualitative Detection by PCR, Plasma) or HIV-1 RNA (HIVQN / HIV-1 RNA Detection and Quantification, Plasma).
New York State clients: This test should not be requested for maternal/newborn HIV screening on specimens originating in New York State, due to state regulatory requirements for expedited result reporting.
Specimen Required
Collection Container/Tube: Lavender top (EDTA)
Submission Container/Tube: Plastic vial
Specimen Volume: 4 mL
Collection Instructions:
1. Centrifuge blood collection tube per collection tube manufacturer's instructions (eg, centrifuge and aliquot within 2 hours of collection for BD Vacutainer tubes).
2. Aliquot plasma into a plastic vial.
Useful For
Screening for HIV-1 and HIV-2 infection in nonsymptomatic, nonpregnant individuals older than 2 years
This test is not offered as a screening or confirmatory test for blood donor specimens
Reflex Tests
Test ID | Reporting Name | Available Separately | Always Performed |
---|---|---|---|
HVDIP | HIV Ab Confirm / Differentiation, P | Yes | No |
HIVQN | HIV-1 RNA Detect/Quant, P | Yes | No |
Testing Algorithm
This test begins with HIV-1/-2 antigen and antibody screen by chemiluminescence immunoassay. If the screen result is reactive, then HIV-1/-2 antibody confirmation/differentiation test by immunochromatographic method is performed at an additional charge.
If the HIV-1/-2 antibody confirmation/differentiation test is negative for both HIV-1 antibody and HIV-2 antibody, or indeterminate/negative for HIV-1/-2 antibody, or indeterminate/indeterminate for HIV-1/HIV-2 antibody, then HIV-1 RNA detection and quantification is performed at an additional charge.
For more information, see HIV Testing Algorithm (Fourth-Generation Screening Assay), Including Follow-up of Reactive Rapid Serologic Test Results.
Special Instructions
Method Name
Chemiluminescent Microparticle Immunoassay
Reporting Name
HIV-1/-2 Ag and Ab Screen, PSpecimen Type
PlasmaSpecimen Minimum Volume
1.2 mL
Specimen Stability Information
Specimen Type | Temperature | Time | Special Container |
---|---|---|---|
Plasma | Refrigerated (preferred) | 6 days | |
Frozen | 30 days |
Reference Values
Negative
Day(s) Performed
Monday through Saturday
Report Available
1 to 2 daysPerforming Laboratory

Test Classification
This test has been cleared, approved, or is exempt by the US Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.CPT Code Information
87389
G0475
LOINC Code Information
Test ID | Test Order Name | Order LOINC Value |
---|---|---|
HVCOP | HIV-1/-2 Ag and Ab Screen, P | 56888-1 |
Result ID | Test Result Name | Result LOINC Value |
---|---|---|
HIVC3 | HIV-1/-2 Ag and Ab Screen, P | 56888-1 |
Forms
If not ordering electronically, complete, print, and send 1 of the following:
-General Request (T239)