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Test ID KI67B Ki-67(MIB-1), Breast, Quantitative Immunohistochemistry, Automated

Ordering Guidance

Ki-67 immunohistochemistry testing on intracystic papillary carcinoma and solid papillary carcinoma, without clearly stating invasive carcinoma, is not appropriate and will be canceled without processing.


If ordering for diagnostic purposes, order PATHC / Pathology Consultation and request the stain.

Shipping Instructions

Attach the green pathology address label included in the kit to the outside of the transport container.

Necessary Information

1. Pathologist's name, address, and phone number are required.

2. Include accompanying pathology report stating the final diagnosis. If not available, a preliminary diagnosis is acceptable only if it refers to invasive or metastatic breast carcinoma.

Specimen Required

Supplies: Pathology Packaging Kit (T554)

Specimen Type: Preferred: Formalin-fixed, paraffin-embedded tissue block containing invasive or metastatic breast carcinoma

Acceptable: 2 Unstained sections, containing invasive or metastatic breast carcinoma, on charged slides cut at 4 microns less than 1 month ago. Tissue on the slides should have been fixed in 10% neutral buffered formalin. Also send one hematoxylin and eosin-stained slide if possible.

Submission Container/Tube: Pathology Packaging Kit

Collection Instructions: Submit paraffin-embedded invasive or metastatic breast carcinoma tissue.

Additional Information: Paraffin block will be returned with the final report.


If not ordering electronically, complete, print, and send 1 of the following forms with the specimen:

-Oncology Test Request (T729)

-Immunohistochemical (IHC)/In Situ Hybridization (ISH) Stains Request (T763)

Useful For

Determining proliferation of tumor cells in paraffin-embedded tissue blocks from patients diagnosed with breast carcinoma

Reflex Tests

Test ID Reporting Name Available Separately Always Performed
KIBM Ki67 Breast IHC Manual No No

Testing Algorithm

Cases that are not able to be scanned for automated analysis will be changed to the manual process for analysis.

Method Name

Immunohistochemistry, Automated Quantitation

Reporting Name

Ki67 Breast IHC Automated

Specimen Type


Specimen Stability Information

Specimen Type Temperature Time Special Container
Special Ambient (preferred)

Reference Values

Varies by tumor type; values reported from 0% to 100%

Day(s) Performed

Monday through Friday

Report Available

4 to 6 days

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Test Classification

This test was developed, and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the US Food and Drug Administration.

CPT Code Information


LOINC Code Information

Test ID Test Order Name Order LOINC Value
KI67B Ki67 Breast IHC Automated 85330-9


Result ID Test Result Name Result LOINC Value
70995 Interpretation 85330-9
70996 Participated in the Interpretation No LOINC Needed
70997 Report electronically signed by 19139-5
70999 Material Received 81178-6
MA023 Tumor type 44638-5
MA024 Tumor classification 21918-8
71627 Disclaimer 62364-5
71841 Case Number 80398-1