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Test ID MCSTP MayoComplete Solid Tumor Panel, Next-Generation Sequencing, Tumor

Ordering Guidance

Multiple oncology (cancer) gene panels are available. For more information see Oncology Somatic NGS Testing Guide.

Necessary Information

Pathology report (final or preliminary) at minimum containing the following information must accompany specimen for testing to be performed:

1. Patient name

2. Block number-must be on all blocks, slides, and paperwork (can be handwritten on the paperwork)

3. Tissue collection date

4. Source of the tissue

Specimen Required

This assay requires at least 20% tumor nuclei. However, 40% tumor is preferred.

-Preferred amount of tumor area: 720 mm(2) tissue on up to 20 unstained slides

-Minimum amount of tumor area: 192 mm(2) tissue on up to 20 unstained slides

-Tissue fixation: 10% neutral buffered formalin, not decalcified

-For this test, at least 6 mm x 6 mm areas on 20 unstained slides is preferred: this is approximately equivalent to 720 mm(2). The minimum acceptable area is 3.1mm x 3.1mm on 20 unstained slides: approximately equivalent to 192 mm(2).



Specimen Type: Tissue block

Collection Instructions: Submit a formalin-fixed, paraffin-embedded tissue block with an acceptable amount of tumor tissue



Specimen Type: Tissue slide

Slides: 1 stained and 20 unstained

Collection Instructions: Submit 1 hematoxylin and eosin (H and E) stained slide and 20 unstained, nonbaked 5-micron thick sections

Note: The total amount of required tumor can be obtained by scraping up to 20 slides from the same block.


Specimen Type: Cytology slides (direct smears or ThinPrep)

Slides: 2 to 6 slides

Collection Instructions: Submit 2 to 6 stained and coverslipped slides with a preferred total of 10,000 nucleated cells or a minimum of at least 6,000 nucleated cells

Note: Glass coverslips are preferred; plastic coverslips are acceptable but will result in longer turnaround times.

Additional Information: Cytology slides will not be returned. An image of the slides will be stored per regulatory requirements.

Useful For

Assisting in tumor profiling for diagnosis, predicting prognosis, and identifying targeted therapies for the treatment and management of patients with solid tumors


Identifying somatic alterations including single nucleotide variants, small deletions/insertions, gene amplifications, fusions, and splice variants in genes known to be associated with the tumorigenesis of solid tumors


Assessment of microsatellite instability and tumor mutational burden status

Additional Tests

Test ID Reporting Name Available Separately Always Performed
SLIRV Slide Review in MG No, (Bill Only) Yes

Testing Algorithm

When this test is ordered, slide review will always be performed at an additional charge to ensure specimen adequacy.

Method Name

Sequence Capture and Targeted Next-Generation Sequencing (NGS)

Reporting Name

MayoComplete Solid Tumor Panel

Specimen Type


Specimen Minimum Volume

See Specimen Required

Specimen Stability Information

Specimen Type Temperature Time Special Container
Varies Ambient (preferred)

Reference Values

An interpretive report will be provided.

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Test Classification

This test was developed, and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the US Food and Drug Administration.

CPT Code Information


81479 (if appropriate for gov't payors)


LOINC Code Information

Test ID Test Order Name Order LOINC Value
MCSTP MayoComplete Solid Tumor Panel 73977-1


Result ID Test Result Name Result LOINC Value
610425 Result 82939-0
610426 Interpretation 69047-9
610427 Additional Information 48767-8
610428 Clinical Trials 82786-5
610429 Variants of Uncertain Significance 93367-1
610430 Specimen 31208-2
610431 Tissue ID 80398-1
610432 Method 85069-3
610433 Disclaimer 62364-5
610434 Released By 18771-6

Day(s) Performed

Monday through Friday

Report Available

14 to 21 days


If not ordering electronically, complete, print, and send a Oncology Test Request (T729) with the specimen.