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Test ID NIUCR Nickel/Creatinine Ratio, Random, Urine

Ordering Guidance

This test is preferred for the determination of nickel exposure, but serum concentrations can be used to verify an elevated urine concentration. For more information see NIS / Nickel, Serum.

Specimen Required

Patient Preparation: High concentrations of gadolinium and iodine are known to interfere with most metal tests. If gadolinium- or iodine-containing contrast media has been administered, a specimen should not be collected for 96 hours.

Supplies: Urine Tubes, 10 mL (T068)

Container/Tube: Plastic, 10-mL urine tube or clean, plastic aliquot container with no metal cap or glued insert

Specimen Volume: 3 mL

Collection Instructions:

1. Collect a random urine specimen

2. See Trace Metals Analysis Specimen Collection and Transport for complete instructions.

Useful For

Preferred specimen type for biomonitoring nickel exposure

Profile Information

Test ID Reporting Name Available Separately Always Performed
NIUC Nickel/Creat Ratio, U No Yes
CRETR Creatinine, Random, U No Yes

Method Name

NIUC: Inductively Coupled Plasma-Mass Spectrometry (ICP-MS)

CRETR: Enzymatic Colorimetric Assay

Reporting Name

Nickel/Creat Ratio, Random, U

Specimen Type


Specimen Minimum Volume

1.2 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Urine Refrigerated (preferred) 28 days
  Frozen  28 days
  Ambient  14 days

Reference Values


0-17 years: not established

Males ≥18 years: <3.8 mcg/g creatinine

Females ≥18 years: <4.3 mcg/g creatinine



16-326 mg/dL

Reference values have not been established for patients younger than 18 years of age.

Day(s) Performed


Report Available

2 to 8 days

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Test Classification

This test was developed, and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the US Food and Drug Administration.

CPT Code Information



LOINC Code Information

Test ID Test Order Name Order LOINC Value
NIUCR Nickel/Creat Ratio, Random, U 13472-6


Result ID Test Result Name Result LOINC Value
CRETR Creatinine, Random, U 2161-8
614553 Nickel/Creat Ratio, U 13472-6