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Test ID NMH1D N-Methylhistamine, 24 Hour, Urine


Ordering Guidance


Random urine collection is preferred for patients with episodic symptoms, eg, in the context of allergic reactions, brought on by specific environmental factors; order NMHR / N-Methylhistamine, Random, Urine.



Specimen Required


Only orderable as part of a profile. For more information see NMH24 / N-Methylhistamine, 24 Hour, Urine.

 

Patient Preparation: Patient must not be taking monoamine oxidase inhibitors (MAOIs) or aminoguanidine as these medications increase N-methylhistamine (NMH) levels.

Supplies: Sarstedt Aliquot Tube, 5 mL (T914)

Container/Tube: Plastic, 5-mL tube

Specimen Volume: 5 mL

Collection Instructions:

1. Collect urine for 24 hours.

2. No preservative.

3. Aliquot into plastic tube and send at refrigerate temperature.


Useful For

Screening for and monitoring of mastocytosis and disorders of systemic mast-cell activation, such as anaphylaxis and other forms of severe systemic allergic reactions as a part of a profile

 

Monitoring therapeutic progress in conditions that are associated with secondary, localized, low-grade persistent, mast-cell proliferation and activation such as interstitial cystitis

Method Name

Only orderable as part of a profile. For more information see NMH24 / N-Methylhistamine, 24 Hour, Urine.

 

Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS)

Reporting Name

N-Methylhistamine, 24 Hr, U

Specimen Type

Urine

Specimen Stability Information

Specimen Type Temperature Time
Urine Refrigerated (preferred) 28 days
  Ambient  28 days
  Frozen  28 days

Reference Values

Only orderable as part of a profile. For more information see NMH24 / N-Methylhistamine, 24 Hour, Urine.

 

0-5 years: 120-510 mcg/g creatinine

6-16 years: 70-330 mcg/g creatinine

>16 years: 30-200 mcg/g creatinine

Day(s) Performed

Monday, Wednesday, Friday

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.

CPT Code Information

82542

LOINC Code Information

Test ID Test Order Name Order LOINC Value
NMH1D N-Methylhistamine, 24 Hr, U 44340-8

 

Result ID Test Result Name Result LOINC Value
605159 N-Methylhistamine, 24 Hr 44340-8

Report Available

3 to 7 days

Specimen Minimum Volume

3 mL