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Test ID PK1 Pyruvate Kinase Enzyme Activity, Blood

Specimen Required

Collection Container/Tube:

Preferred: Yellow top (ACD solution B)

Acceptable: Lavender top (EDTA)

Specimen Volume: 6 mL

Collection Instructions: Send specimen in original tube. Do not transfer blood to other containers.

Useful For

Evaluation of nonspherocytic hemolytic anemia


Evaluation of neonatal anemia or jaundice


Evaluation of unexplained noninfectious hepatic failure


Evaluation of unexplained iron overload


Evaluation of unusually severe hemoglobin S trait


Evaluation of unusually severe glucose 6-phosphate dehydrogenase deficiency


Investigating families with pyruvate kinase deficiency to determine inheritance pattern and for genetic counseling

Method Name

Kinetic Spectrophotometry

Reporting Name

PK Enzyme Activity, B

Specimen Type

Whole Blood ACD-B

Specimen Minimum Volume

1 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Whole Blood ACD-B Refrigerated 20 days

Reference Values

≥12 months of age: 5.5-12.4 U/g Hb

Reference values have not been established for patients who are less than12 months of age.

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Test Classification

This test was developed, and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the US Food and Drug Administration.

CPT Code Information


LOINC Code Information

Test ID Test Order Name Order LOINC Value
PK1 PK Enzyme Activity, B 32552-2


Result ID Test Result Name Result LOINC Value
PKCL PK Enzyme Activity, B 32552-2

Day(s) Performed

Monday through Friday

Report Available

1 to 4 days