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Test ID PLABN Platelet Antibody Screen, Serum

Useful For

Detecting alloantibodies to epitopes on platelet glycoproteins IIb/IIIa, Ib/Ix, Ia/IIa, IV and class I human leukocyte antigens (HLA) to evaluate cases of immune mediated refractoriness to platelet transfusions, posttransfusion purpura, or neonatal alloimmune thrombocytopenia

Method Name

Solid Phase Enzyme-Linked Immunosorbent Assay (ELISA)

Reporting Name

Platelet Ab Screen, S

Specimen Type

Serum Red

Ordering Guidance

For neonate testing, consider sending a maternal specimen instead of a neonate specimen as unbound platelet antibodies may not be detected in the neonate serum.


This test is not recommended for the diagnosis of immune thrombocytopenia (ITP) or autoimmune thrombocytopenia. Tests that are optimized to detect antibodies bound to the platelets will be useful in these situations; cell-bound platelet antibody (direct) test is strongly recommended.

Necessary Information

If ordering electronically, answer all prompt questions for timely result reporting:

1. Reason for request is required for result interpretation.

 a. Use provided diagnosis options if appropriate. If specific diagnosis is unknown, select the generic answer of alloimmune thrombocytopenia.

 b. Record only the diagnosis pertaining to this test.

 c. Record diagnosis description instead of code.

2. Indicate if patient has had intravenous immunoglobulin (IVIg) therapy in the last month: Yes or No

3. Indicate if the patient has received a platelet transfusion within 72 hours of collection (Transfused platelets will interfere with assay): Yes or No

4. Record the most recent platelet count, if available. If not available, enter "Not Available." Platelet count conversion: 93 x10(9)/L =93 x10(6)/mL =93 x 10(3)/microliter

Specimen Required

Patient Preparation: Do not collect within 72 hours of a platelet transfusion. Transfused platelets will interfere with this assay.

Collection Container/Tube: Red top

Submission Container/Tube: Plastic vial

Specimen Volume: 1.5 mL

Collection Instructions: Centrifuge and aliquot serum into a plastic vial.

Specimen Minimum Volume

0.5 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Serum Red Frozen (preferred) 365 days
  Refrigerated  48 hours

Reference Values

Not applicable

Day(s) Performed

Monday through Friday

Report Available

2 to 4 days

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Test Classification

This test has been cleared, approved, or is exempt by the US Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.

CPT Code Information


LOINC Code Information

Test ID Test Order Name Order LOINC Value
PLABN Platelet Ab Screen, S 95270-5


Result ID Test Result Name Result LOINC Value
PTL01 Overall Result 24375-8
PTL02 Interpretation 59466-3
PTL03 GPIIb/IIIa (Cell-1) 48505-2
PTL04 GPIIb/IIIa (Cell-2) 48505-2
PTL05 GPIa/IIa (Cell-1) 47084-9
PTL06 GPIa/IIa (Cell-2) 47084-9
PTL07 GPIb/IX 48506-0
PTL08 GPIV 87757-1
PTL09 HLA Class I 95269-7
PTL15 Reason for request? 29548-5
PTL16 IVIg in last month? 95268-9
PTL17 Plt Transfusion in last 72 hours? 95268-9
PTL18 Platelet Count x 10(9)/L? 26515-7

Testing Algorithm

For more information see Platelet Antibody Testing Algorithm.