Home
HelpTest ID PNBX Peripheral Nerve Pathology Consultation
Additional Testing Requirements
Biopsies from same site will be processed as 1 specimen. Biopsies from different sites require separate orders and separate specimen vials.
Examples:
1. Three (3) segments vials of left sural nerve are processed as 1 specimen, 1 order number.
2. One (1) left sural nerve and 1 left superficial peroneal nerve requires 2 separate orders.
Shipping Instructions
Transport specimen per Nerve Biopsy Specimen Preparation Instruction (T580).
Necessary Information
The following information is required:
1. Nerve Biopsy Patient Information (T458) is required, containing the following information:
-Tentative clinical diagnosis
-Name of nerve biopsied
-Date of biopsy
-Indication for nerve biopsy
2. A copy of the Neurology Clinical Notes and electromyography (EMG) results are required for testing.
All requisition and supporting information must be submitted in English.
Specimen Required
Specimen Type: Nerve biopsy tissue, slides, or block
Collection Instructions: Prepare and transport specimen per Nerve Biopsy Specimen Preparation Instruction (T580). A Nerve Biopsy Kit (call 507-284-8065 to order) containing fixatives and buffer is available for an additional fee.
Forms
1. Nerve Biopsy Patient Information (T458) is required
2. Pathology/Cytology Information (T707)
Useful For
Evaluating diseases of the nerve and disorders that affect nerve function
Reflex Tests
| Test ID | Reporting Name | Available Separately | Always Performed |
|---|---|---|---|
| SS2PC | SpecStain, Grp II, other | No, (Bill Only) | No |
| COSPC | Consult, Outside Slide | No, (Bill Only) | No |
| CUPPC | Consult, w/USS Prof | No, (Bill Only) | No |
| CRHPC | Consult, w/Comp Rvw of His | No, (Bill Only) | No |
| NTFPC | Teased Fiber | No, (Bill Only) | No |
| IHPCI | IHC Initial | No, (Bill Only) | No |
| IHPCA | IHC Additional | No, (Bill Only) | No |
| LV4RP | Level 4 Gross and Microscopic, RB | No, (Bill Only) | No |
| CSPPC | Consult, w/Slide Prep | No, (Bill Only) | No |
| EM | Electron Microscopy | Yes, (Bill Only) | No |
Testing Algorithm
A battery of enzyme histochemical stains or immunostains are performed; other tests can be performed as indicated at an additional charge. The reviewing neuromuscular pathologist will determine the need for additional testing.
Wet tissue for consultation: When adequate tissue is provided, routine testing will include teased fiber examination, Congo red stain, methyl violet stain, Masson's trichrome stain, leukocyte common antigen, luxol fast blue/PAS (periodic acid-Schiff) stain, KP-1 macrophage, methylene blue stain, hematoxylin and eosin stain, and Turnbull blue stain or Perl's Prussian blue stain.
Slides and blocks sent for consultation: Special stains and studies performed on the case should be sent with the case for review. In order to determine an accurate diagnosis, some of these stains or studies may be deemed to warrant repeat testing, at an additional charge, at the discretion of the reviewing Mayo Clinic neuromuscular pathologist. In addition, testing requested by the referring physician (immunostains, molecular studies, etc) may not be performed if deemed unnecessary by the reviewing Mayo Clinic neuromuscular pathologist. For all consultations, ancillary testing necessary to determine a diagnosis is ordered at the discretion of the Mayo Clinic neuromuscular pathologist. An interpretation, which includes an evaluation of the specimen and determination of a diagnosis, will be provided within a formal pathology report.
For more information see Pathology Consultation Ordering Algorithm.
Special Instructions
Method Name
Nerve Biopsy Surgical Pathology Consultation and Review of Outside Material
Reporting Name
Peripheral Nerve Path ConsultSpecimen Type
VariesSpecimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Varies | Refrigerated (preferred) | ||
| Frozen | |||
Reference Values
An interpretive report will be provided.
Day(s) Performed
Monday through Friday
Report Available
7 to 14 days: Cases requiring additional material or ancillary testing may require additional time.Performing Laboratory
Mayo Clinic Laboratories in Rochester
Test Classification
This test was developed, and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the US Food and Drug Administration.CPT Code Information
88305 (if appropriate)
88313 (if appropriate)
88321 (if appropriate)
88323 (if appropriate)
88323-26 (if appropriate)
88325 (if appropriate)
88362 (if appropriate)
88348 (if appropriate)
88342 (if appropriate)
88341 (if appropriate)
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| PNBX | Peripheral Nerve Path Consult | In Process |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| 601774 | Interpretation | 59465-5 |
| 601775 | Participated in the Interpretation | No LOINC Needed |
| 601776 | Report electronically signed by | 19139-5 |
| 601777 | Addendum | 35265-8 |
| 601778 | Gross Description | 22634-0 |
| 601779 | Material Received | 81178-6 |
| 601823 | Case Number | 80398-1 |
| 601912 | Disclaimer | 62364-5 |
Specimen Minimum Volume
4.5 cm biopsy