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Test ID PNBX Peripheral Nerve Pathology Consultation

Additional Testing Requirements

Biopsies from same site will be processed as 1 specimen. Biopsies from different sites require separate orders and separate specimen vials.


1. Three (3) segments vials of left sural nerve are processed as 1 specimen, 1 order number.

2. One (1) left sural nerve and 1 left superficial peroneal nerve requires 2 separate orders.

Shipping Instructions

Transport specimen per Nerve Biopsy Specimen Preparation Instruction (T580).

Necessary Information

The following information is required:

1. Nerve Biopsy Patient Information (T458) is required, containing the following information:

-Tentative clinical diagnosis

-Name of nerve biopsied

-Date of biopsy

-Indication for nerve biopsy

2. A copy of the Neurology Clinical Notes and electromyography (EMG) results are required for testing.


All requisition and supporting information must be submitted in English.

Specimen Required

Specimen Type: Nerve biopsy tissue, slides, or block

Collection Instructions: Prepare and transport specimen per Nerve Biopsy Specimen Preparation Instruction (T580). A Nerve Biopsy Kit (call 507-284-8065 to order) containing fixatives and buffer is available for an additional fee.

Useful For

Evaluating diseases of the nerve and disorders that affect nerve function

Reflex Tests

Test ID Reporting Name Available Separately Always Performed
SS2PC SpecStain, Grp II, other No, (Bill Only) No
COSPC Consult, Outside Slide No, (Bill Only) No
CUPPC Consult, w/USS Prof No, (Bill Only) No
CRHPC Consult, w/Comp Rvw of His No, (Bill Only) No
NTFPC Teased Fiber No, (Bill Only) No
IHPCI IHC Initial No, (Bill Only) No
IHPCA IHC Additional No, (Bill Only) No
LV4RP Level 4 Gross and Microscopic, RB No, (Bill Only) No
CSPPC Consult, w/Slide Prep No, (Bill Only) No
EM Electron Microscopy Yes, (Bill Only) No

Testing Algorithm

A battery of enzyme histochemical stains or immunostains are performed; other tests can be performed as indicated at an additional charge. The reviewing neuromuscular pathologist will determine the need for additional testing.


Wet tissue for consultation: When adequate tissue is provided, routine testing will include teased fiber examination, Congo red stain, methyl violet stain, Masson's trichrome stain, leukocyte common antigen, luxol fast blue/PAS (periodic acid-Schiff) stain, KP-1 macrophage, methylene blue stain, hematoxylin and eosin stain, and Turnbull blue stain or Perl's Prussian blue stain.


Slides and blocks sent for consultation: Special stains and studies performed on the case should be sent with the case for review. In order to determine an accurate diagnosis, some of these stains or studies may be deemed to warrant repeat testing, at an additional charge, at the discretion of the reviewing Mayo Clinic neuromuscular pathologist. In addition, testing requested by the referring physician (immunostains, molecular studies, etc) may not be performed if deemed unnecessary by the reviewing Mayo Clinic neuromuscular pathologist. For all consultations, ancillary testing necessary to determine a diagnosis is ordered at the discretion of the Mayo Clinic neuromuscular pathologist. An interpretation, which includes an evaluation of the specimen and determination of a diagnosis, will be provided within a formal pathology report.


For more information see Pathology Consultation Ordering Algorithm.

Method Name

Nerve Biopsy Surgical Pathology Consultation and Review of Outside Material

Reporting Name

Peripheral Nerve Path Consult

Specimen Type


Specimen Stability Information

Specimen Type Temperature Time Special Container
Varies Refrigerated (preferred)

Reference Values

An interpretive report will be provided.

Day(s) Performed

Monday through Friday

Report Available

7 to 14 days: Cases requiring additional material or ancillary testing may require additional time.

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Test Classification

This test was developed, and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the US Food and Drug Administration.

CPT Code Information

88305 (if appropriate)

88313 (if appropriate)

88321 (if appropriate)

88323 (if appropriate)

88323-26 (if appropriate)

88325 (if appropriate)

88362 (if appropriate)

88348 (if appropriate)

88342 (if appropriate)

88341 (if appropriate)

LOINC Code Information

Test ID Test Order Name Order LOINC Value
PNBX Peripheral Nerve Path Consult In Process


Result ID Test Result Name Result LOINC Value
601774 Interpretation 59465-5
601775 Participated in the Interpretation No LOINC Needed
601776 Report electronically signed by 19139-5
601777 Addendum 35265-8
601778 Gross Description 22634-0
601779 Material Received 81178-6
601823 Case Number 80398-1
601912 Disclaimer 62364-5

Specimen Minimum Volume

4.5 cm biopsy