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Test ID POWVS Powassan Virus, RNA, Molecular Detection, PCR, Serum

Ordering Guidance

The Powassan virus polymerase chain reaction result may remain positive for a longer time in urine than in blood, serum, and cerebrospinal fluid (7 days or more).

Additional Testing Requirements

This test is designed to be used during the first 7 days after symptom onset and should be ordered in conjunction with POWV / Powassan Virus, IgM, Enzyme-Linked Immunosorbent Assay, Serum.

Specimen Required

Collection Container/Tube:

Preferred: Serum gel

Acceptable: Red top

Submission Container: Plastic vial

Specimen Volume: 0.5 mL

Collection Instructions:

1. Centrifuge and aliquot serum into a plastic vial within 2 hours of collection.

2. Label specimen as serum

Useful For

Rapid testing for Powassan virus RNA (lineage 1 and lineage 2) using serum specimens


An adjunctive test to serology for detection of early Powassan virus infection (ie, first few days after symptom onset)


This assay should not be used for screening asymptomatic individuals and should only be used to test patients with signs and symptoms of Powassan virus disease.

Method Name

Real-Time Polymerase Chain Reaction (PCR)

Reporting Name

Powassan Virus, PCR, Serum

Specimen Type


Specimen Minimum Volume

0.3 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Serum Refrigerated (preferred) 7 days
  Frozen  7 days

Reference Values


Day(s) Performed

Monday through Friday

Report Available

Same day/1 to 5 days

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Test Classification

This test was developed, and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the US Food and Drug Administration.

CPT Code Information


LOINC Code Information

Test ID Test Order Name Order LOINC Value
POWVS Powassan Virus, PCR, Serum 55144-0


Result ID Test Result Name Result LOINC Value
617490 Lineage 1 55144-0
618146 Lineage 2 (Deer Tick Virus) 55144-0
618150 Powassan Virus PCR Comment 77202-0


If not ordering electronically, complete, print, and send a Microbiology Test Request (T732) with the specimen.