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Test ID PSYQP Psychotropic Pharmacogenomics Gene Panel, Varies

Necessary Information

Prior Authorization is available for this test. Submit the required form with the specimen. 

Specimen Required

Prior Authorization is available for this test. Submit the required form with the specimen.


Submit only 1 of the following specimens:


Specimen Type: Whole blood

Container/Tube: Lavender top (EDTA)

Specimen Volume: 3 mL

Collection Instructions:

1. Invert several times to mix blood.

2. Send whole blood specimen in original tube. Do not aliquot.

Specimen Stability Information: Ambient (preferred) 9 days/Refrigerated 30 days


Specimen Type: Saliva

Patient Preparation: Patient should not eat, drink, smoke, or chew gum 30 minutes prior to collection.

Supplies: Saliva Swab Collection Kit (T786)

Specimen Volume: 2 Swabs, use 2 kits for collection

Collection Instructions: Collect and send specimen per kit instructions.

Additional Information: Due to lower concentration of DNA yielded from saliva, testing cannot proceed to reflex testing for CYP2D6 sequencing and will stop after initial testing is complete.

Specimen Stability Information: Ambient 30 days


Specimen Type: Extracted DNA

Container/Tube: 2-mL screw top tube

Specimen Volume: 100 mcL (microliters)

Collection Instructions:

1. The preferred volume is 100 mcL at a concentration of 50 ng/mcL.

2. Provide concentration of DNA and volume on tube.

Specimen Stability Information: Frozen (preferred) 1 year/Ambient/Refrigerated


1. New York Clients-Informed consent is required. Document on the request form or electronic order that a copy is on file. The following documents are available:

-Informed Consent for Genetic Testing (T576)

-Informed Consent for Genetic Testing-Spanish (T826)

2. Psychotropic Pharmacogenomics Gene Panel Prior Authorization Ordering Instructions

3. If not ordering electronically, complete, print, and send a Therapeutics Test Request (T831) with the specimen.

Useful For

Individualizing selection and dosage of medications prescribed for treatment of depression and other psychiatric disorders based on genetic variation


Identifying genetic variation in genes known to be associated with response and/or risk of toxicity with psychotropic medications


Evaluating patients who have failed therapy with selective serotonin reuptake inhibitors (SSRI)


Evaluating patients with treatment-resistant depression


Predicting response time to improvement with SSRI

Testing Algorithm

If a specimen requires follow-up for CYP2D6, then reflex testing will be performed as appropriate at an additional charge.


For more information, see CYP2D6 Comprehensive Cascade Testing Algorithm.

Method Name

Real-Time Polymerase Chain Reaction (RT-PCR) with Allelic Discrimination Analysis/Qualitative Allele-Specific RT-PCR/PCR followed by Sizing Analysis

Reporting Name

Psychotropic PGx Panel, V

Specimen Type


Specimen Minimum Volume

Blood: 1 mL
Saliva, extracted DNA: see Specimen Required

Specimen Stability Information

Specimen Type Temperature Time Special Container
Varies Varies

Reference Values

An interpretive report will be provided.

Day(s) Performed

Monday through Thursday

Report Available

3 to 14 days

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Test Classification

This test was developed, and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the US Food and Drug Administration.

CPT Code Information


LOINC Code Information

Test ID Test Order Name Order LOINC Value
PSYQP Psychotropic PGx Panel, V 94753-1


Result ID Test Result Name Result LOINC Value
610209 ADRA2A rs1800544 Genotype 94401-7
610210 ANKK1 rs1800497 Genotype 94402-5
610211 CHRNA3 rs1051730 Genotype 94403-3
610212 COMT rs4680 Genotype 74511-7
610213 CYP1A2 Genotype 72884-0
610214 CYP1A2 Phenotype 94254-0
610215 CYP2B6 Genotype 72882-4
610216 CYP2B6 Phenotype 79720-9
610573 CYP2B6 Activity Score In Process
610217 CYP2C19 Genotype 57132-3
610218 CYP2C19 Phenotype 79714-2
610574 CYP2C19 Activity Score In Process
610219 CYP2C9 Genotype 46724-1
610220 CYP2C9 Phenotype 79716-7
610575 CYP2C9 Activity Score In Process
610221 CYP2D6 Genotype 40425-1
610222 CYP2D6 Phenotype 79715-9
610576 CYP2D6 Activity Score In Process
610223 CYP3A4 Genotype 81139-8
610224 CYP3A4 Phenotype 81145-5
610225 CYP3A5 Genotype 81140-6
610226 CYP3A5 Phenotype 79717-5
610227 DRD2 rs1799978 Genotype 94411-6
610228 EPHX1 rs2234922 Genotype 94412-4
610229 GRIK4 rs1954787 Genotype 94413-2
610230 HLA-A*31:01 Genotype 79712-6
610231 HLA-B*15:02 Genotype 57979-7
610232 HTR2A rs7997012 Genotype 93190-7
610233 HTR2C rs3813929 Genotype 93191-5
610234 HTR2C rs1414334 Genotype 93192-3
610235 MTHFR Genotype 94414-0
610236 OPRM1 rs1799971 Genotype 94415-7
610237 SCN1A rs3812718 Genotype 94416-5
610238 SLC6A4 5HTTLPR Genotype 94417-3
610239 UGT2B15 rs1902023 Genotype 94418-1
610240 Interpretation 69047-9
610241 Additional Information 48767-8
610242 Method 85069-3
610243 Disclaimer 62364-5
610244 Reviewed by 18771-6

Reflex Tests

Test ID Reporting Name Available Separately Always Performed
2D61Z CYP2D6 Full Gene Sequence No, (Bill Only) No
2D62Z CYP2D6 GEN CYP2D6-2D7 Hybrid No, (Bill Only) No
2D63Z CYP2D6 GEN CYP2D7-2D6 Hybrid No, (Bill Only) No
2D64Z CYP2D6 Nonduplicated Gene No, (Bill Only) No
2D65Z CYP2D6 5' Gene DUP/MLT No, (Bill Only) No
2D66Z CYP2D6 3' Gene DUP/MLT No, (Bill Only) No

Prior Authorization

Insurance preauthorization is available for this testing; forms are available.

Patient financial assistance may be available to those who qualify. Patients who receive a bill from Mayo Clinic Laboratories will receive information on eligibility and how to apply.