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Test ID RAPAN Rheumatoid Arthritis Panel, Serum

Ordering Guidance

This test is the optimal first-line antibody panel for evaluating patients at-risk for rheumatoid arthritis.

The following testing may also be useful:

ENAE / Antibody to Extractable Nuclear Antigen Evaluation, Serum

ADNAR / DNA Double-Stranded (dsDNA) Antibodies with Reflex, IgG, Serum

NAIFA / Antinuclear Antibodies, HEp-2 Substrate, IgG, Serum

CTDC / Connective Tissue Diseases Cascade, Serum

Specimen Required

Collection Container/Tube:

Preferred: Serum gel

Acceptable: Red top

Submission Container/Tube: Plastic vial

Specimen Volume: 2 mL

Collection Instructions: Centrifuge and aliquot serum into a plastic vial.

Useful For

Evaluating patients suspected of having rheumatoid arthritis (RA)


Differentiating RA from other inflammatory arthritis or connective tissue diseases


Diagnosis and stratification of rheumatoid arthritis

Profile Information

Test ID Reporting Name Available Separately Always Performed
CCP Cyclic Citrullinated Peptide Ab, S Yes Yes
RHUT Rheumatoid Factor, S Yes Yes

Special Instructions

Method Name

CCP: Enzyme-Linked Immunosorbent Assay (ELISA)

RHUT: Turbidimetry

Reporting Name

Rheumatoid Arthritis Panel, S

Specimen Type


Specimen Minimum Volume

1.2 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Serum Refrigerated (preferred) 14 days
  Frozen  14 days

Reference Values

Cyclic Citrullinated Peptide Antibodies, IgG

<20.0 U (negative)

20.0-39.9 U (weak positive)

40.0-59.9 U (positive)

≥60.0 U (strong positive)

Reference values apply to all ages.


Rheumatoid Factor

<15 IU/mL

Day(s) Performed

Monday through Saturday

Report Available

2 to 3 days

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Test Classification

This test has been cleared, approved, or is exempt by the US Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.

CPT Code Information



LOINC Code Information

Test ID Test Order Name Order LOINC Value
RAPAN Rheumatoid Arthritis Panel, S 46437-0


Result ID Test Result Name Result LOINC Value
CCP Cyclic Citrullinated Peptide Ab, S 33935-8
RHUT Rheumatoid Factor, S 11572-5