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HelpTest ID RAVU Ravulizumab, Serum
Ordering Guidance
To screen test complement abnormalities in the alternative pathway, order RAVUM / Ravulizumab Complement Blockage Monitoring, Serum.
Specimen Required
Patient Preparation: Natalizumab or eculizumab must be discontinued at least 4 weeks prior to testing for ravulizumab quantitation in serum.
Preferred: Red top
Acceptable: Serum gel
Submission Container/Tube: Plastic vial
Specimen Volume: 2.5 mL
Collection Instructions:
1. Draw blood immediately before next scheduled dose.
2. Centrifuge and aliquot serum into a plastic vial within 2 hours of collection.
Useful For
Assessing the response to ravulizumab therapy
Assessing the need for dose escalation
Evaluating the potential for dose de-escalation or discontinuation of therapy in remission states
Monitoring patients who need to be above a certain ravulizumab concentration in order to improve the odds of a clinical response for therapy optimization
This test is not useful as the sole basis for a diagnosis or treatment decisions.
Method Name
Liquid Chromatography-Tandem Mass Spectrometry, High Resolution Accurate Mass (LC-MS/MS HRAM)
Reporting Name
Ravulizumab, SSpecimen Type
SerumSpecimen Minimum Volume
1.1 mL
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Serum | Refrigerated (preferred) | 28 days | |
| Ambient | 28 days | ||
| Frozen | 28 days |
Reference Values
Lower limit of quantitation=5.0 mcg/mL
>175 mcg/mL-Therapeutic concentration for paroxysmal nocturnal hemoglobinuria and atypical hemolytic uremic syndrome
Performing Laboratory
Mayo Clinic Laboratories in Rochester
Test Classification
This test was developed, and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the US Food and Drug Administration.CPT Code Information
80299
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| RAVU | Ravulizumab, S | 97184-6 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| 609420 | Ravulizumab, S | 97184-6 |
Day(s) Performed
Wednesday
Report Available
3 to 9 daysForms
If not ordering electronically, complete, print, and send a Coagulation Test Request (T753) with the specimen.