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Test ID RPRT1 Rapid Plasma Reagin (RPR) Screen with Reflex to Titer, Serum

Ordering Guidance

This test is for monitoring response to therapy in patients treated for syphilis infection. This test should not be used as a primary diagnostic approach for syphilis. To screen for undiagnosed syphilis infection, order SYPH1 / Syphilis IgG with Reflex, Enzyme Immunoassay, Serum

Specimen Required

Collection Container/Tube:

Preferred: Serum gel

Acceptable: Red top

Submission Container/Tube: Plastic vial

Specimen Volume: 0.5 mL

Collection Instructions: Centrifuge and aliquot serum into a plastic vial.

Useful For

Determining the current disease status


Monitoring response to therapy for syphilis


Aid to diagnose congenital syphilis


This test cannot be used for testing spinal fluid specimens.


This test is not intended for medical-legal use.

Reflex Tests

Test ID Reporting Name Available Separately Always Performed
RPRT2 RPR Titer,S No No

Testing Algorithm

If this test is positive, then the rapid plasma reagin titer will be performed at an additional charge.

Method Name


Reporting Name

RPR Screen w/ Reflex to Titer,S

Specimen Type


Specimen Minimum Volume

0.4 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Serum Refrigerated (preferred) 14 days
  Frozen  14 days

Reference Values


Reference values apply to all ages.

Day(s) Performed

Monday through Saturday

Report Available

Same day/1 to 4 days

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Test Classification

This test has been cleared, approved, or is exempt by the US Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.

CPT Code Information


86593-Rapid Plasma Reagin Titer (if appropriate)

LOINC Code Information

Test ID Test Order Name Order LOINC Value
RPRT1 RPR Screen w/ Reflex to Titer,S 20507-0


Result ID Test Result Name Result LOINC Value
616863 RPR Screen w/ Reflex to Titer,S 20507-0


If not ordering electronically, complete, print, and send Infectious Disease Serology Test Request (T916) with the specimen.