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Test ID T790M Cell-Free DNA EGFR T790M Mutation Analysis, Blood

Ordering Guidance

This test is not a prenatal screening test.


This test detects only the T790M mutation in the EGFR gene. It does not detect other EGFR gene mutations in exons 18 through 21.


This test provides rapid detection of the EGFR T790M mutation in whole blood specimens from non-small cell lung cancer patients as an alternative for EGFR analysis of tissue. For tissue testing, order EGFRS / EGFR Gene, Targeted Mutation Analysis, 51 Mutation Panel, Tumor.

Shipping Instructions


Specimen Required

Supplies: Streck Black/Tan Top Tube Kit (T715)

Container/Tube: 10-mL Streck cell-free DNA (cfDNA) tubes

Specimen Volume: Two 10-mL Streck cfDNA tubes

Additional Information: Only blood collected in Streck Cell-Free DNA BCT will be accepted for analysis. Whole blood will be processed to produce platelet poor plasma before cfDNA isolation.

Useful For

Determination of EGFR T790M mutation status in blood specimens as an alternative to invasive tissue biopsies


Identification of patients with non-small cell lung cancer who harbor a T790M mutation and may benefit from specific epidermal growth factor receptor (EGFR)-targeted therapies

Method Name

Droplet Digital Polymerase Chain Reaction (PCR)

Reporting Name

cfDNA EGFR T790M Test, Blood

Specimen Type

Whole blood

Specimen Minimum Volume

One 10 mL Streck tube

Specimen Stability Information

Specimen Type Temperature Time Special Container
Whole blood Ambient (preferred) 7 days Streck Black/Tan top
  Refrigerated  7 days Streck Black/Tan top

Day(s) Performed

Monday through Friday

Report Available

5 to 10 days

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Test Classification

This test was developed, and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the US Food and Drug Administration.

CPT Code Information


LOINC Code Information

Test ID Test Order Name Order LOINC Value
T790M cfDNA EGFR T790M Test, Blood 55769-4


Result ID Test Result Name Result LOINC Value
113411 Result Summary 50397-9
113412 Result 55769-4
113413 Interpretation 69047-9
113414 Additional Information 48767-8
113415 Specimen 31208-2
113416 Source 31208-2
113417 Released By 18771-6


If not ordering electronically, complete, print, and send an Oncology Test Request (T729) with the specimen.