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Test ID TLTE4 Leukotriene E4, 24 Hour, Urine

Ordering Guidance

Random urine collections are preferred for patients with episodic symptoms, eg, in the context of allergic reactions brought on by specific environmental factors or mast cell activation syndrome. For random urine collection, order RLTE4 / Leukotriene E4, Random, Urine.

Additional Testing Requirements

For an optimal evaluation, testing for urinary leukotriene E4 should be accompanied with laboratory investigations for the presence of serum tryptase (TRYPT / Tryptase, Serum), urinary 2,3-dinor 11 beta-prostaglandin F2 alpha (23BPT / 2,3-Dinor 11 Beta-Prostaglandin F2 Alpha, 24 Hour, Urine) and urinary N-methylhistamine (NMH24 / N-Methylhistamine, 24 Hour, Urine).

Necessary Information

Specimen volume and duration are required.

Specimen Required

Supplies: Sarstedt Aliquot Tube, 5 mL (T914)

Container/Tube: Plastic vial

Specimen Volume: 5 mL

Collection Instructions:

1. Start collection within a few hours of symptom onset and collect urine for 24 hours

2. No preservative preferred

3. Aliquot urine into a plastic vial and send frozen.

Additional Information: See Urine Preservatives-Collection and Transportation for 24-Hour Urine Specimens for multiple collection.

Profile Information

Test ID Reporting Name Available Separately Always Performed
LTE4T Leukotriene E4, 24 Hr, U No Yes
CRT2F Creatinine, 24 HR, U No Yes

Method Name

LTE4T: Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS)

CRT2F: Enzymatic Colorimetric Assay

Reporting Name

Leukotriene E4, 24 Hr, U

Specimen Type


Specimen Minimum Volume

2 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Urine Frozen (preferred) 28 days
  Refrigerated  7 days
  Ambient  24 hours

Reference Values


≤104 pg/mg creatinine



Normal values mg per 24 hours:

Males: 930-2955 mg/24 hours

Females: 603-1783 mg/24 hours

Reference values have not been established for patients who are younger than 18 years of age.

Day(s) Performed

Monday, Thursday

Report Available

2 to 9 days

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Test Classification

This test was developed, and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the US Food and Drug Administration.

CPT Code Information


LOINC Code Information

Test ID Test Order Name Order LOINC Value
TLTE4 Leukotriene E4, 24 Hr, U In Process


Result ID Test Result Name Result LOINC Value
603458 Leukotriene E4, U 101115-4
CR_AF Creatinine, 24 HR, U 2162-6
TM10F Collection Duration 13362-9
VL8F Urine Volume 3167-4
CRF24 Creatinine Concentration, 24 HR, U 20624-3

Urine Preservative Collection Options

Note: The addition of preservative or application of temperature controls must occur within 4 hours of completion of the collection.







50% Acetic Acid


Boric Acid


Diazolidinyl Urea


6M Hydrochloric Acid


6M Nitric Acid


Sodium Carbonate